Effects of cortisone, hydrocortisone and corticotropin on lipemia, glycemia and atherogenesis in cholesterol-fed chicks.
نویسندگان
چکیده
HUMAN beings with hyperadrenocorticism (e.g. Cushing's syndrome) frequently develop premature, severe atherosclerosis.7' 8 This fact assumes new importance at the present time, when chronic hyperadrenocortical states are being artificially induced on a large scale for therapeutic purposes. The widespread utilization of corticotropin (ACTH) and adrenal steroids in clinical medicine compels a thorough-going examination of their effects on atherogenesis. Towards this end, we previously studied the influences of desoxycorticosterone acetate (DCA) on avian experimental atherosclerosis.9 The present investigation analyzed the effects of cortisone (compound E), hydrocortisone (compound F), and adrenocorticotropic hormone (ACTH)* on blood pressure, lipemia, glyce-
منابع مشابه
Effects of Cortisone , Hydrocortisone and Corticotropin on Lipemia , Glycemia and Atherogenesis in Cholesterol - Fed Chicks
HUMAN beings with hyperadrenocorticism (e.g. Cushing's syndrome) frequently develop premature, severe atherosclerosis.7' 8 This fact assumes new importance at the present time, when chronic hyperadrenocortical states are being artificially induced on a large scale for therapeutic purposes. The widespread utilization of corticotropin (ACTH) and adrenal steroids in clinical medicine compels a tho...
متن کاملThe effect of pancreatectomy on lipemia, tissue lipidosis and atherogenesis in chicks.
Following complete pancreatectomy, chicks exhibit an excessive hypercholesterolemia wshen fed a diet containing cholesterol plus cottonseed oil. This inordinate hypercholesterolemia is accompanied by intensified atherogenesis, compared with unoperated controls on the same diet. Dietary neutral fat is essential for these excessive cholesterolemic and atherogenic responses. The possible significa...
متن کاملEffects of Hypothyroidism on Estrogen-Induced Inhibition of Coronary Atherogenesis in Cholesterol-Fed Cockerels
Five series of experiments were accomplished, utilizing a total of 190 birds. The established methods of the department's atherosclerosis research team were followed throughout. One-day old Hy-Line chicks were obtained from a commercial hatchery and reared in a battery brooder on a diet of commercial chick starter mash. At onset of the study, the birds were divided into experimental groups and ...
متن کاملFurther observations on the effects of thyroid hormone preparations on cholesterolemia and atherogenesis in cholesterol-fed cockerels.
Administration of large doses of thyroid hormone preparations (desiccated thyroid powder, thyroxine, triiodothyronine, diiodotyrosine) to cholesterol-fed chicks was associated with decreased rate of weight gain and partial inhibition of hypercholesterolemia. Consistent, definitive inhibition of aorta and coronary atherogenesis was not observed, despite partial suppression of hypercholesterolemi...
متن کاملThe Effect of Cortisone on the Serum Lipids and on the Development of Experimental Cholesterol Atherosclerosis in the Rabbit
An experiment was performed to determine the effect of cortisone on the serum lipids and on the development of experimental cholesterol atherosclerosis in the rabbit. Litter mate rabbits of the same sex were employed; both sexes were represented in the experiment. The report is based upon four experimental groups comprising (1) 12 rabbits fed cholesterol and treated with cortisone vehicle; (2) ...
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ورودعنوان ژورنال:
- Circulation
دوره 10 2 شماره
صفحات -
تاریخ انتشار 1954